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Pathway activation

For biologists using microarrays or sequencing one of the most intersting things is finding if a pathway related to a function is activated or not.

To know if a pathway is activated or not usually we need to compare the same pathway in two conditions. It means a subject centered functional scoring method. Which in turns assumes that a pathway is conserved among people and time.

In addition the assumption that is done is that more expression of more genes of a pathways imply an increase of the metabolism of that pathway, which might not be true. Given that pathway has 5 genes, and that all of them are positive regulated implies that a pathway is activated?

I have to dive to the origins of this, and see if there is some other way to measure how active a pathway is.


  1. This comment has been removed by a blog administrator.

    1. Hi divya, while I appreciate your effort to introduce me to new courses and languages this is not the topic of the post, so I removed it. If you have more opinions and content relevant to this post let me know.


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